Cingulin-like 1

Cingulin-like 1
Identifiers
Symbol CGNL1
Alt. symbols FLJ14957, JACOP, KIAA1749, paracingulin
Entrez 84952
HUGO 25931
OMIM 607856
RefSeq NM_032866
UniProt Q0VF96
Other data
Locus Chr. 15 q21.3

Cingulin-like 1 is a protein which in humans is encoded by the CGNL1 gene.[1][2]

Function

The mouse homolog of CGNL1 has been designated JACOP (junction-associated coiled-coil protein). JACOP is recruited to the junctional complex in epithelial cells and to cell-cell contacts in fibroblasts. It has been suggested that JACOP is involved in anchoring cell-cell contacts to actin-based cytoskeletons within cells.[3]

References

  1. ^ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970. 
  2. ^ "Entrez Gene: Cingulin-like 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84952. 
  3. ^ Ohnishi H, Nakahara T, Furuse K, Sasaki H, Tsukita S, Furuse M (2004). "JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin". Journal of Biological Chemistry 279 (44): 46014–22. doi:10.1074/jbc.M402616200. PMID 15292197.